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Science 3 October 1980:
Vol. 210. no. 4465, pp. 88 - 90
DOI: 10.1126/science.6251550
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Articles

Science, Vol 210, Issue 4465, 88-90
Copyright © 1980 by American Association for the Advancement of Science

articles

Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding

SJ Peroutka and SH Snyder

Antidepressants compete at several neurotransmitter receptor binding site, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and beta-adrenergic receptors. The decrease in the number of receptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.


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