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Science 26 September 1980:
Vol. 209. no. 4464, pp. 1545 - 1546
DOI: 10.1126/science.7433977
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Articles

Science, Vol 209, Issue 4464, 1545-1546
Copyright © 1980 by American Association for the Advancement of Science

articles

Mood and behavioral effects of physostigmine on humans are accompanied by elevations in plasma beta-endorphin and cortisol

SC Risch, RM Cohen, DS Janowsky, NH Kalin, and DL Murphy

Administration of physostigmine to normal volunteers produced significant elevations in plasma cortisol and beta-endorphin immunoreactivity as well as alterations in mood, cognition, and behavior. These observations might be explained by a cholinergically mediated stress syndrome. However, peak elevations in plasma beta-endorphin immunoreactivity (but not in plasma cortisol) were significantly correlated with physostigmine-induced increases in depression ratings. These results suggest that a cholinergically mediated beta-endorphin pathway may be involved in the observed affective changes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Cholinergic Rapid Eye Movement Induction Test With Arecoline in Depression.
J. C. Gillin, L. Sutton, C. Ruiz, J. Kelsoe, R. M. Dupont, D. Darko, S. C. Risch, S. Golshan, and D. Janowsky (1991)
Arch Gen Psychiatry 48, 264-270
   Abstract »    PDF »
{beta}-Endorphin/{beta}-Lipotropin Immunoreactivity in Endogenous Depression: Effect of Dexamethasone.
J. Matthews, H. Akil, J. Greden, D. Charney, V. Weinberg, A. Rosenbaum, and S. J. Watson (1986)
Arch Gen Psychiatry 43, 374-381
   Abstract »    PDF »
Co-release of ACTH and beta-endorphin immunoreactivity in human subjects in response to central cholinergic stimulation.
S. Risch, N. Kalin, D. Janowsky, R. Cohen, D Pickar, and D. Murphy (1983)
Science 222, 77
   PDF »


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