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Science 19 September 1980:
Vol. 209. no. 4463, pp. 1431 - 1435
DOI: 10.1126/science.6158096
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Articles

Science, Vol 209, Issue 4463, 1431-1435
Copyright © 1980 by American Association for the Advancement of Science

articles

Effect of interferon-alpha 1 from E. coli on some cell functions

MG Masucci, R Szigeti, E Klein, G Klein, J Gruest, L Montagnier, H Taira, A Hall, S Nagata, and C Weissmann

Interferon-alpha 1 from Escherichia coli transformed with a hybrid plasmid containing a human leukocyte complementary DNA insert, induces resistance to virus in appropriate target cells. It also shares the following properties with natural leukocyte interferon (IFN). (i) It enhances natural killing activity of human lymphocytes, (ii) it enhances antibody-dependent cell-mediated cytotoxicity, (iii) it suppresses antigen- and mitogen-induced leukocyte migration inhibition, (iv) it inhibits growth of IFN-sensitive Burkitt lymphoma cells. Since these activities are exhibited by a cloned protein species, they are due to IFN itself and not to other human proteins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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L. Edwards, N. Levine, M. Weidner, M. Piepkorn, and K. Smiles (1986)
Arch Dermatol 122, 779-782
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Leukocyte-Derived Interferon (Alpha) in Human Breast Carcinoma: The American Cancer Society Phase II Trial.
E. C. BORDEN, J. F. HOLLAND, T. L. DAO, J. U. GUTTERMAN, L. WIENER, Y.-C. CHANG, and J. PATEL (1982)
Ann Intern Med 97, 1-6
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Clinical and Immunologic Effects of Recombinant Leukocyte A Interferon in Eight Patients With Advanced Cancer.
S. J. Horning, J. F. Levine, R. A. Miller, S. A. Rosenberg, and T. C. Merigan (1982)
JAMA 247, 1718-1722
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Interferon: Immunobiology and Clinical Significance.
E. R. STIEHM, L. H. KRONENBERG, H. M. ROSENBLATT, Y. BRYSON, and T. C. MERIGAN (1982)
Ann Intern Med 96, 80-93
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Oncology.
E. M. McKelvey (1981)
JAMA 245, 2209-2211
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