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Science 19 September 1980:
Vol. 209. no. 4463, pp. 1375 - 1380
DOI: 10.1126/science.6251544
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Articles

Science, Vol 209, Issue 4463, 1375-1380
Copyright © 1980 by American Association for the Advancement of Science

articles

The origins of gene instability in yeast

GS Roeder, PJ Farabaugh, DT Chaleff, and GR Fink

Two unstable mutations at the his4 locus of yeast are due to the insertion of the transposable elements Ty912 and Ty917 into the his4 regulatory region. The two transposons are related, one being derived from the other by a substitution of 4000 base pairs of DNA. Element Ty912 includes identical terminal repeats, whereas the terminal repeats of Ty917 are not identical. Transposition of Ty912 or Ty917 generates 5-base-pair duplications of the target DNA at either end of the element. Expression and reversion of a his4 gene containing Ty912 or Ty917 is controlled by three unlinked regulatory genes. The properties of these regulatory genes are similar to those described for the controlling elements in maize.


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