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Science 19 September 1980:
Vol. 209. no. 4463, pp. 1348 - 1353
DOI: 10.1126/science.6774414
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Articles

Science, Vol 209, Issue 4463, 1348-1353
Copyright © 1980 by American Association for the Advancement of Science

articles

Mapping of heavy chain genes for mouse immunoglobulins M and D

CP Liu, PW Tucker, JF Mushinski, and FR Blattner

A single DNA fragment containing both mu and delta immunoglobulin heavy chain genes has been cloned from normal BALB/c mouse liver DNA with a new lambda phage vector Charon 28. The physical distance between the membrane terminal exon of mu and the first domain of delta is 2466 base pairs, with delta on the 3' side of mu. A single transcript could contain a variable region and both mu and delta constant regions. The dual expression of immunoglobulins M and D on spleen B cells may be due to alternate splicing of this transcript.


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