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Science 12 September 1980:
Vol. 209. no. 4462, pp. 1242 - 1245
DOI: 10.1126/science.7403881
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Articles

Science, Vol 209, Issue 4462, 1242-1245
Copyright © 1980 by American Association for the Advancement of Science

articles

Cerebral arteriolar damage by arachidonic acid and prostaglandin G2

HA Kontos, EP Wei, JT Povlishock, WD Dietrich, CJ Magiera, and EF Ellis

Application of arachidonic acid or prostaglandin G(2) to the brain surface of anesthetized cats induced cerebral arteriolar damage. Scavengers of free oxygen radicals inhibited this damage. Prostaglandin H(2), prostaglandin E(2), and 11,14,17-eicosatrienoic acid did not produce arteriolar damage. It appears that increased prostaglandin synthesis produces cerebral vascular damage by generating free oxygen radicals.


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