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Science 5 September 1980:
Vol. 209. no. 4461, pp. 1138 - 1140
DOI: 10.1126/science.7403874
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Articles

Science, Vol 209, Issue 4461, 1138-1140
Copyright © 1980 by American Association for the Advancement of Science

articles

Alterations in brain norepinephrine metabolism induced by environmental stimuli previously paired with inescapable shock

G Cassens, M Roffman, A Kuruc, PJ Orsulak, and JJ Schildkraut

Footshock stress produced an immediate increase in brain concentrations of 3-methoxy-4-hydroxyphenylglycol sulfate (MHPG-SO4), a major metabolite of the neurotransmitter norepinephrine, in the rat brain. Twenty-four hours after footshock stress, when concentrations had returned to baseline, increases in MHPG-SO4 and emotional behavior could be elicited by previously neutral environmental stimuli that had been paired with the stress.


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