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Science 5 September 1980:
Vol. 209. no. 4461, pp. 1128 - 1132
DOI: 10.1126/science.6250219
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Articles

Science, Vol 209, Issue 4461, 1128-1132
Copyright © 1980 by American Association for the Advancement of Science

articles

J genes for heavy chain immunoglobulins of mouse

N Newell, JE Richards, PW Tucker, and FR Blattner

A 15,8-kilobase pair fragment of BALB/c mouse liver DNA, cloned in the Charon 4A lambda phage vector system, was shown to contain the mu heavy chain constant region (CHmu) gene for the mouse immunoglobulin M. In addition, this fragment of DNA contains at least two J genes, used to code for the carboxyl terminal portion of heavy chain variable regions. These genes are located in genomic DNA about eight kilobase pairs to the 5' side of the CHmu gene. The complete nucleotide sequence of a 1120-base pair stretch of DNA that includes the two J genes has been determined.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structural Patterns in Anti-DNA Antibodies from MRL/lpr Mice.
M.Z. Radic, M.A. Mascelli, J. Erikson, H. Shan, M. Shlomchik, and M. Weigert (1989)
Cold Spring Harb Symp Quant Biol 54, 933-946
   Abstract »    PDF »
Homologous recombination catalyzed by mammalian cell extracts in vitro.
V Darby and F Blattner (1984)
Science 226, 1213-1215
   Abstract »    PDF »
Mapping of heavy chain genes for mouse immunoglobulins M and D.
C. Liu, P. Tucker, J. Mushinski, and F. Blattner (1980)
Science 209, 1348-1353
   Abstract »    PDF »


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