Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 29 August 1980:
Vol. 209. no. 4460, pp. 976 - 983
DOI: 10.1126/science.6157191

Articles

Science, Vol 209, Issue 4460, 976-983
Copyright © 1980 by American Association for the Advancement of Science


articles

Brain peptides as neurotransmitters

SH Snyder

Numerous peptides appear to be neurotransmitter candidates in the brain. Some, such as the opioid peptide enkephalins, neurotensin, and substance P, were first isolaterd from the brain. Peptides, such as cholecystokinin and vasoactive intestinal polypeptide, were known as intestinal hormones and later recognized as brain constituents. Certain hypothalamic-releasing hormones, pituitary peptides, and blood-derived peptides like angiotensin II and bradykinin, may also be central neurotransmitters. The diversity of localization of these peptides throughout the brain implies a multiplicity of potential roles.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Quantitative trait loci and psychopharmacology: response to commentaries.
R. Plomin, G. E. McClearn, and G. Gora-Maslak (1991)
J Psychopharmacol 5, 23-28
   Abstract »    PDF »
Chemical anatomy of the brain.
T Hokfelt, O Johansson, and M Goldstein (1984)
Science 225, 1326-1334
   Abstract »
Brain peptides: what, where, and why?.
D. Krieger (1983)
Science 222, 975-985
   Abstract »    PDF »
Regional brain concentrations of neuropeptides in Huntington's chorea and schizophrenia.
C. Nemeroff, W. Youngblood, P. Manberg, A. Prange Jr, and J. Kizer (1983)
Science 221, 972-975
   Abstract »    PDF »
Selective, naloxone-reversible morphine depression of learned behavioral and hippocampal responses.
M. Mauk, J. Warren, and R. Thompson (1982)
Science 216, 434-436
   Abstract »    PDF »
Substance P in principal sympathetic neurons: regulation by impulse activity.
J. Kessler, J. Adler, M. Bohn, and I. Black (1981)
Science 214, 335-336
   Abstract »    PDF »
Pentapeptide (proctolin) associated with an identified neuron.
M O'Shea and M. Adams (1981)
Science 213, 567-569
   Abstract »    PDF »



ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)