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Science 29 August 1980:
Vol. 209. no. 4460, pp. 976 - 983
DOI: 10.1126/science.6157191
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Articles

Science, Vol 209, Issue 4460, 976-983
Copyright © 1980 by American Association for the Advancement of Science

articles

Brain peptides as neurotransmitters

SH Snyder

Numerous peptides appear to be neurotransmitter candidates in the brain. Some, such as the opioid peptide enkephalins, neurotensin, and substance P, were first isolaterd from the brain. Peptides, such as cholecystokinin and vasoactive intestinal polypeptide, were known as intestinal hormones and later recognized as brain constituents. Certain hypothalamic-releasing hormones, pituitary peptides, and blood-derived peptides like angiotensin II and bradykinin, may also be central neurotransmitters. The diversity of localization of these peptides throughout the brain implies a multiplicity of potential roles.


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