Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 29 August 1980:
Vol. 209. no. 4460, pp. 1039 - 1043
DOI: 10.1126/science.6996095
Prev | Table of Contents | Next

Articles

Science, Vol 209, Issue 4460, 1039-1043
Copyright © 1980 by American Association for the Advancement of Science

articles

Nitropyrenes: isolation, identificaton, and reduction of mutagenic impurities in carbon black and toners

HS Rosenkranz, EC McCoy, DR Sanders, M Butler, DK Kiriazides, and R Mermelstein

Extracts of selected xerographic toners and copies were found to be mutagenic in the Salmonella assay. The activity was independent of the xerographic hardware and process and was traced to nitropyrenes present as impurities in the carbon black, the toner colorant. Manufacturing process changes resulted in a substantial reduction of the nitropyrene content of the carbon black and thus in the mutagenicity of the corresponding toners. Nitropyrenes are potent frameshift mutagens, and possible mechanisms for their biological action are discussed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Comparative Mutagenesis of the C8-Guanine Adducts of 1-Nitropyrene and 1,6- and 1,8-Dinitropyrene in a CpG Repeat Sequence. A SLIPPED FRAMESHIFT INTERMEDIATE MODEL FOR DINUCLEOTIDE DELETION.
P. Hilario, S. Yan, B. E. Hingerty, S. Broyde, and A. K. Basu (2002)
J. Biol. Chem. 277, 45068-45074
   Abstract »    Full Text »    PDF »
Mutagenicity of a single 1-nitropyrene-DNA adduct N-(deoxyguanosin-8-yl)-1-aminopyrene in Escherichia coli located in a GGC sequence.
M. D. Bacolod and A. K. Basu (2001)
Mutagenesis 16, 461-465
   Abstract »    Full Text »    PDF »
Recognition and incision of site-specifically modified C8 guanine adducts formed by 2-aminofluorene, N-acetyl-2-aminofluorene and 1-nitropyrene by UvrABC nuclease.
C. Luo, R. Krishnasamy, A. K. Basu, and Y. Zou (2000)
Nucleic Acids Res. 28, 3719-3724
   Abstract »    Full Text »    PDF »
Oxygen-Insensitive Nitroreductases: Analysis of the Roles of nfsA and nfsB in Development of Resistance to 5-Nitrofuran Derivatives in Escherichia coli.
J. Whiteway, P. Koziarz, J. Veall, N. Sandhu, P. Kumar, B. Hoecher, and I. B. Lambert (1998)
J. Bacteriol. 180, 5529-5539
   Abstract »    Full Text »
Acute Toxicity Studies of Xerox Reprographic Toners.
G. H. Y. Lin and R. Mermelstein (1994)
International Journal of Toxicology 13, 2-20
   Abstract »    PDF »
Studies on environmental chemical carcinogenesis in Japan.
T Sugimura (1986)
Science 233, 312-318
   Abstract »    PDF »
Health Effects of Exposure to Diesel Engine Emissions: A Summary of Animal Studies Conducted by the U.S. Environmental Protection Agency's Health Effects Research Laboratories at Cincinnati, Ohio.
W. E. Pepelko and W. B. Peirano (1983)
International Journal of Toxicology 2, 253-306
   Abstract »    PDF »
Detection of mutagens in complex samples by the Salmonella assay applied directly on thin-layer chromatography plates.
A Bjorseth, G Eidsa, J Gether, L Landmark, and M Moller (1982)
Science 215, 87-89
   Abstract »    PDF »
Mutagenic activity in photocopies.
G Lofroth, E Hefner, I Alfheim, and M Mooller (1980)
Science 209, 1037-1039
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)