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Science 29 August 1980:
Vol. 209. no. 4460, pp. 1026 - 1028
DOI: 10.1126/science.6773144
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Articles

Science, Vol 209, Issue 4460, 1026-1028
Copyright © 1980 by American Association for the Advancement of Science

articles

Gap junction development is correlated with insulin content in the pancreatic B cell

P Meda, P Halban, A Perrelet, AE Renold, and L Orci

The development of gap junctions between insulin-containing B cells was quantitatively analyzed in islets of Langerhans isolated from rats treated with the sulfonylurea glibenclamid for 1, 2, or 7 days. Glibenclamid treatment was associated with a marked depletion of the insulin content of B cells and with an increase in the number and size of gap junctions between these cells. A significance correlation was found between these two events.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Z. Ling, Q. Wang, G. Stange, P. In't Veld, and D. Pipeleers (2006)
Diabetes 55, 78-85
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Hyperinsulinemia-Induced Hypoglycemia Is Enhanced by Overexpression of Connexin 43.
C. Vozzi, D. Bosco, E. Dupont, A. Charollais, and P. Meda (1997)
Endocrinology 138, 2879-2885
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Islets of Langerhans: dye coupling among immunocytochemically distinct cell types.
R. Michaels and J. Sheridan (1981)
Science 214, 801-803
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