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Science 29 August 1980:
Vol. 209. no. 4460, pp. 1023 - 1026
DOI: 10.1126/science.7403864
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Articles

Science, Vol 209, Issue 4460, 1023-1026
Copyright © 1980 by American Association for the Advancement of Science

articles

Testosterone-mediated sexual dimorphism of mitochondria and lysosomes in mouse kidney proximal tubules

H Koenig, A Goldstone, G Blume, and CY Lu

In kidney proximal tubules of male mice the mitochondria are larger and more electron-lucent, autophagic vacuoles and lysosomes (predominantly myeloid bodies) more numerous and voluminous, and exocytosed intraluminal myeloid bodies more common than in females. Males also have higher kidney activities of mitochondrial cytochrome c oxidase and lysosomal hydrolases, and excrete larger quantities of hydrolases and protein in the urine. Orchiectomy evokes the feminine pattern whereas testosterone administration induces the male pattern. Endogenous testosterone modulates mitochondrial structure and function and enhances the activity of the lysosomal-vacuolar system in proximal tubule cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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M. P. Hutchens, J. Dunlap, P. D. Hurn, and P. O. Jarnberg (2008)
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Sex-differential expression of ornithine aminotransferase in the mouse kidney.
O. Levillain, G. Ventura, H. Dechaud, M. Hobeika, A. Meseguer, C. Moinard, and L. Cynober (2007)
Am J Physiol Renal Physiol 292, F1016-F1027
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Influence of dietary arginine on the anabolic effects of androgens.
A Cremades, C Ruzafa, F Monserrat, A J Lopez-Contreras, and R Penafiel (2004)
J. Endocrinol. 183, 343-351
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Influence of Sex Differences on the Renal Secretion of Organic Anions.
J. L. Reyes, E. Melendez, A. Alegria, and F. Jaramillo-Juarez (1998)
Endocrinology 139, 1581-1587
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