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Science 22 August 1980:
Vol. 209. no. 4459, pp. 942 - 944
DOI: 10.1126/science.6250218
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Articles

Science, Vol 209, Issue 4459, 942-944
Copyright © 1980 by American Association for the Advancement of Science

articles

Pituitary gonadotropin-releasing hormone receptors during the rat estrous cycle

RT Savoy-Moore, NB Schwartz, JA Duncan, and JC Marshall

The binding of [6-alanine]gonadotropin-releasing hormone to pituitary plasma membranes increased threefold between metestrus and early proestrus in female rats. Receptor numbers fell rapidly on the afternoon of proestrus coincident with the preovulatory gonadotropin surge. The numbers of receptors for gonadotropin-releasing hormone were positively correlated with concentrations of estradiol in serum; this pattern may be a necessary component of increased pituitary sensitivty to gonadotropin-releasing hormone observed during proestrus.


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