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Science 15 August 1980:
Vol. 209. no. 4458, pp. 827 - 828
DOI: 10.1126/science.6250217
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Articles

Science, Vol 209, Issue 4458, 827-828
Copyright © 1980 by American Association for the Advancement of Science

articles

Dexamethasone fails to suppress beta-endorphin plasma concentrations in humans and rhesus monkeys

NH Kalin, SC Risch, RM Cohen, T Insel, and DL Murphy

In humans and rhesus monkeys, dexamethasone decreased concentrations of plasma cortisol but did not alter circulating beta-endorphin immunoreactivity. Contrary to current theory suggesting that pituitary beta-endorphin and adrenocorticotropic hormone are controlled by identical regulatory mechanisms for synthesis and release, our evidence suggests that in higher primates the established glucocorticoid feedback mechanism for the adrenocorticotropic hormone-cortisol system does not regulate beta-endorphin secretion in the same way.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{beta}-Endorphin/{beta}-Lipotropin Immunoreactivity in Endogenous Depression: Effect of Dexamethasone.
J. Matthews, H. Akil, J. Greden, D. Charney, V. Weinberg, A. Rosenbaum, and S. J. Watson (1986)
Arch Gen Psychiatry 43, 374-381
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