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Science 15 August 1980:
Vol. 209. no. 4458, pp. 823 - 825
DOI: 10.1126/science.6250216
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Articles

Science, Vol 209, Issue 4458, 823-825
Copyright © 1980 by American Association for the Advancement of Science

articles

Vitamin D deficiency inhibits pancreatic secretion of insulin

AW Norman, JB Frankel, AM Heldt, and GM Grodsky

The effects of a vitamin D deficiency on insulin and glucagon release was determined in the isolated perfused rat pancreas by radioimmunoassay of the secreted proteins. During a 30-minute period of perfusion with glucose and arginine, pancreases from vitamin D-deficient rats exhibited a 48 percent reduction in insulin secretion compared to that for pancreases from vitamin D-deficient rats that had been replenished with vitamin D. Vitamin D status had no effect on pancreatic glucagon secretion. This result, along with the previously demonstrated presence in the pancreas of a vitamin D-dependent calcium-binding protein and cytosol receptor for the hormonal form of vitamin D, 1,25-dihydroxyvitamin D3, indicates an important role for vitamin D in the endocrine functioning of the pancreas.


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