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Science 15 August 1980:
Vol. 209. no. 4458, pp. 815 - 817
DOI: 10.1126/science.6157189
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Articles

Science, Vol 209, Issue 4458, 815-817
Copyright © 1980 by American Association for the Advancement of Science

articles

Histamine-mediated delayed permeability response after scald burn inhibited by cimetidine or cold-water treatment

JV Boykin Jr, E Eriksson, MM Sholley, and RN Pittman

Scald injury to one ear of the hairless mouse induced significant (P < .05) delayed edema formation in remote, uninjured skin. This remote edema formation was completely inhibited by immediate cold-water treatment of the scalded ear. Cold-water treatment significantly reduced histamine loss from the scalded ear, and the edema-inhibiting effect of the treatment could be mimicked by treating the animal prior to injury with the H2-histamine receptor antagonist cimetidine or a drug that causes histamine depletion. These observations suggest (i) that a histamine-mediated, delayed permeability response occurs after thermal injury that causes remote edema formation and (ii) that one mechanism of remote edema inhibition by cold-water treatment is the prevention of histamine release from thermally injured tissues.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transcapillary forces of the subcutaneous tissue in patients with coronary artery disease: a comparison between pulsatile and nonpulsatile flow during extracorporeal circulation.
K. A Rein, D. Aune, O. W Levang, R. Stenseth, and H. O Myhre (1988)
Perfusion 3, 187-194
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