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Science 8 August 1980:
Vol. 209. no. 4457, pp. 711 - 713
DOI: 10.1126/science.7394532
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Articles

Science, Vol 209, Issue 4457, 711-713
Copyright © 1980 by American Association for the Advancement of Science

articles

Neuronal loss in hippocampus induced by prolonged ethanol consumption in rats

DW Walker, DE Barnes, SF Zornetzer, BE Hunter, and P Kubanis

Quantitative neurohistological techniques were used to examine the hippocampal complex of laboratory rats maintained on ethanol-containing or control diets for 5 months followed by a 2-month alcohol-free period. Chronic ethanol consumption resulted in a significant loss of hippocampal pyramidal and dentate gyrus granule cells. This study provides direct evidence that long-term ethanol consumption, in the absence of malnutrition, produces neuronal loss in the central nervous system.


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