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Science 8 August 1980:
Vol. 209. no. 4457, pp. 708 - 710
DOI: 10.1126/science.7394531
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Articles
Science, Vol 209, Issue 4457, 708-710
Copyright © 1980 by American Association for the Advancement of Science
Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex
JN Nestoros
Ethanol (ethyl alcohol) potentiates the inhibition of cortical neurons by gamma-aminobutyric acid. This effect is specific, since ethanol does not potentiate inhibiton by glycine, serotonin, or dopamine. These results have implications for alcoholism because (i) gamma-aminobutyric acid mediates anxiolytic mechanisms, and (ii) anxiety is implicated in the etiology of alcoholism.
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