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Science 8 August 1980:
Vol. 209. no. 4457, pp. 701 - 702
DOI: 10.1126/science.6994231
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Articles

Science, Vol 209, Issue 4457, 701-702
Copyright © 1980 by American Association for the Advancement of Science

articles

Estrogen and the growth of breast cancer: new evidence suggests indirect action

SM Shafie

The growth of the MCF-7 human breast cancer cell line is unresponsive to the presence of estrogen in culture media. Paradoxically, in nude mice, growth of these cells and formation of solid tumors are dependent on estrogen. Tumors fail to develop in ovariectomized mice, but do develop in intact mice and in ovariectomized mice given estrogen. Primary cultures derived from MCF-7 tumors revert to unresponsiveness to estrogen. However, when these cultures are again transplanted into nude mice, estrogen is required for tumor formation. The continuous culture, the solid tumor, and the primary cultures therefrom have similar estrogen-binding capacities and affinities. These results indicate that mammary carcinoma cell growth in vivo is subject to inhibition that can be overcome by estrogen.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Endocr. Relat. Cancer 16, 333-350
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A Century of Deciphering the Control Mechanisms of Sex Steroid Action in Breast and Prostate Cancer: The Origins of Targeted Therapy and Chemoprevention.
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Basic Guide to the Mechanisms of Antiestrogen Action.
J. I. Macgregor and V. C. Jordan (1998)
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Transfection of v-rasH DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity.
A Kasid, M. Lippman, A. Papageorge, D. Lowy, and E. Gelmann (1985)
Science 228, 725-728
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Human endometrial adenocarcinoma transplanted into nude mice: growth regulation by estradiol.
P. Satyaswaroop, R. Zaino, and R Mortel (1983)
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