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Science 1 August 1980:
Vol. 209. no. 4456, pp. 609 - 671
DOI: 10.1126/science.6771872
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Articles

Science, Vol 209, Issue 4456, 609-671
Copyright © 1980 by American Association for the Advancement of Science

articles

Effective pulmonary ventilation with small-volume oscillations at high frequency

AS Slutsky, FM Drazen, RH Ingram Jr, RD Kamm, AH Shapiro, JJ Fredberg, SH Loring, and J Lehr

At high oscillation frequencies (4 to 30 hertz), effective alveolar ventilation can be achieved with tidal volumes much smaller than the anatomic dead space. An explanation of this phenomenon is given in terms of the combined effects of diffusion and convection and in terms of data consistent with the hypothesis. Theory and experimental results both show that the significant variable determining the effectiveness of gas exchange is the amplitude of the oscillatory flow rate independent of the individual values of frequency and stroke volume.


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