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Science 25 July 1980:
Vol. 209. no. 4455, pp. 521 - 523
DOI: 10.1126/science.7394520
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Articles

Science, Vol 209, Issue 4455, 521-523
Copyright © 1980 by American Association for the Advancement of Science

articles

Excitatory and inhibitory effects of serotonin on sensorimotor reactivity measured with acoustic startle

M Davis, DI Strachan, and E Kass

Serotonin infused into the lateral ventricle in rats produced a dose-dependent depression of the acoustic startle reflex. When infused onto the spinal cord, serotonin produced a dose-dependent increase in startle. Thus the same neurotransmitter can modulate the same behavior in opposite ways, depending on which part of the central nervous system is involved.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Interactions between Depression and Facilitation within Neural Networks: Updating the Dual-Process Theory of Plasticity.
S. A. Prescott (1998)
Learn. Mem. 5, 446-466
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Multiple serotonergic influences on startle responding.
M. A. Geyer (1991)
J Psychopharmacol 5, 334-335
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Sensorimotor Gating and Schizophrenia: Human and Animal Model Studies.
D. L. Braff and M. A. Geyer (1990)
Arch Gen Psychiatry 47, 181-188
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Science. ISSN 0036-8075 (print), 1095-9203 (online)