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Science 25 July 1980:
Vol. 209. no. 4455, pp. 507 - 509
DOI: 10.1126/science.6248961
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Articles

Science, Vol 209, Issue 4455, 507-509
Copyright © 1980 by American Association for the Advancement of Science

articles

(-)Pentobarbital opens ion channels of long duration in cultured mouse spinal neurons

DA Mathers and JL Barker

Intracellular recordings from voltage-clamped mouse spinal neurons in tissue culture were used to study the membrane mechanisms underlying inhibitory responses to gamma-aminobutyric acid and the (-) isomer of pentobarbital. Fluctuation analysis suggested that both substances activated ion channels in the membranes. However, the channels activated by pentobarbital remained open five times longer than those activated by gamma-aminobutyric acid.


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{gamma}-Aminobutyric Acid (GABA) and Pentobarbital Induce Different Conformational Rearrangements in the GABAA Receptor {alpha}1 and {beta}2 Pre-M1 Regions.
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Molecular Basis for Modulation of Recombinant {alpha}1{beta}2{gamma}2 GABAA Receptors by Protons.
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J Neurophysiol 92, 883-894
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Conductance of GABAA Channels Activated by Pentobarbitone in Hippocampal Neurons from Newborn Rats.
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J. Physiol. 552, 13-22
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Pentobarbital Modulates gamma -Aminobutyric Acid-Activated Single-Channel Conductance in Rat Cultured Hippocampal Neurons.
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Light-Induced Phase Shifts and Fos Expression in the Hamster Circadian System: The Effects of Anesthetics.
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Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.
M. Majewska, N. Harrison, R. Schwartz, J. Barker, and S. Paul (1986)
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General anesthetics hyperpolarize neurons in the vertebrate central nervous system.
R. Nicoll and D. Madison (1982)
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