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Science 25 July 1980:
Vol. 209. no. 4455, pp. 503 - 505
DOI: 10.1126/science.6771871
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Articles

Science, Vol 209, Issue 4455, 503-505
Copyright © 1980 by American Association for the Advancement of Science

articles

Limitations of metabolic activation systems used with in vitro tests for carcinogens

CA Bigger, JE Tomaszewski, A Dipple, and RS Lake

Important differences between the metabolic activation of 7,12-dimethylbenz[a]anthracene in intact cellular systems and in liver homogenates suggest that the use of homogenates in conjunction with short-term assays for carcinogens could yield misleading results.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Both ({+/-})syn- and ({+/-})anti-7,12-Dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides Initiate Tumors in Mouse Skin That Possess -CAA- to -CTA- Mutations at Codon 61 of c-H-ras.
M.-s. Tang, S. V. Vulimiri, A. Viaje, J. X. Chen, D. S. Bilolikar, R. J. Morris, R. G. Harvey, T. J. Slaga, and J. DiGiovanni (2000)
Cancer Res. 60, 5688-5695
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