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Science 18 July 1980:
Vol. 209. no. 4454, pp. 418 - 420
DOI: 10.1126/science.7384816
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Articles

Science, Vol 209, Issue 4454, 418-420
Copyright © 1980 by American Association for the Advancement of Science

articles

The testicular feminized rat: a naturally occurring model of androgen independent brain masculinization

BH Shapiro, DC Levine, and NT Adler

Although genotypically male (XY), the testicular feminized rat develops as an anatomic female because of an inherited deficiency in intracellular androgen receptors that prevents androgen imprinting of sexual primordia. However, the ability of testicular feminized rats to exhibit male-like sexual behavior and little feminine sexual behavior suggests that the brain can be masculinized without androgens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Androgen-receptor defect abolishes sex differences in nitric oxide and reactivity to vasopressin in rat aorta.
J. N. Stallone, R. L. Salisbury, and C. T. Fulton (2001)
J Appl Physiol 91, 2602-2610
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Gonadal hormones induce dendritic growth in the adult avian brain.
T DeVoogd and F Nottebohm (1981)
Science 214, 202-204
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