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Science 18 July 1980:
Vol. 209. no. 4454, pp. 394 - 395
DOI: 10.1126/science.7384811
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Articles

Science, Vol 209, Issue 4454, 394-395
Copyright © 1980 by American Association for the Advancement of Science

articles

Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro

CM Pepper and G Henderson

Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.


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