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Science 11 July 1980:
Vol. 209. no. 4453, pp. 305 - 307
DOI: 10.1126/science.7384808
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Articles

Science, Vol 209, Issue 4453, 305-307
Copyright © 1980 by American Association for the Advancement of Science

articles

Long-lasting depletion of striatal dopamine by a single injection of amphetamine in iprindole-treated rats

RW Fuller and S Hemrick-Luecke

A single injection of amphetamine given to rats treated concurrently with iprindole so that they could not metabolize the amphetamine by para-hydroxylation resulted in a decrease in the concentration of striatal dopamine 1 week later. The decrease was antagonized by amfonelic acid, an inhibitor of uptake into dopamine neurons. The long-lasting depletion of cerebral dopamine by amphetamine may be analogous to the depletion of cerebral serotonin by halogenated derivatives of amphetamine.


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