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Science 11 July 1980:
Vol. 209. no. 4453, pp. 303 - 305
DOI: 10.1126/science.7384806
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Articles

Science, Vol 209, Issue 4453, 303-305
Copyright © 1980 by American Association for the Advancement of Science

articles

Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients

MS Briley, SZ Langer, R Raisman, D Sechter, and E Zarifian

The high-affinity binding of triatiated imipramine to platelet membranes was compared in samples from 16 untreated depressed women and 21 age-matched controls of the same sex. The maximal binding in the depressed group was significantly lower than that of the controls, although the affinity constants were similar. These results suggest that binding of tritiated imipramine in human platelets may represent a biochemical index of depression, possibly reflecting similar changes in the brain.


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