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Science 11 July 1980:
Vol. 209. no. 4453, pp. 294 - 295
DOI: 10.1126/science.6992274
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Articles

Science, Vol 209, Issue 4453, 294-295
Copyright © 1980 by American Association for the Advancement of Science

articles

Mutations in a nonessential viral gene permit bacteriophage T4 to form plaques on Escherichia coli valS ts relA

GL Marchin

During viral development bacteriophage T4 modifies the valyl-transfer RNA synthetase of its host Escherichia coli, but the function of the modification has remained elusive. A strain of Escherichia coli has now been identified which is nonpermissive for wild-type bacteriophage T4, but permissive for bacteriophage mutants impaired in the modification reaction. A comparison with other bacteria suggests that nonpermissiveness is due to synthesis of a thermolabile valyl-transfer RNA synthetase and relaxed control of RNA accumulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bacteriophage T4 Genome.
E. S. Miller, E. Kutter, G. Mosig, F. Arisaka, T. Kunisawa, and W. Ruger (2003)
Microbiol. Mol. Biol. Rev. 67, 86-156
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