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Science 11 July 1980:
Vol. 209. no. 4453, pp. 285 - 287
DOI: 10.1126/science.6155698
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Articles

Science, Vol 209, Issue 4453, 285-287
Copyright © 1980 by American Association for the Advancement of Science

articles

Assignment of the murine interferon sensitivity and cytoplasmic superoxide dismutase genes to chromosome 16

PF Lin, DL Slate, FC Lawyer, and FH Ruddle

Both hybrids of mouse and human microcells and whole cell hybrids generated by the fusion of primary mouse cells and SV40-transformed human fibroblasts were used to establish the syntenic association of the murine cytoplasmic superoxide dismutase and the interferon sensitivity genes on mouse chromosome 16. This assignment adds two new markers to chromosome 16 and provides another example of an evolutionarily conserved linkage. This finding also provides an animal model both for cellular responsiveness to interferon and for Down's syndrome.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetic mapping in mammals: chromosome map of domestic cat.
S. O'Brien and W. Nash (1982)
Science 216, 257-265
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