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Science 27 June 1980:
Vol. 208. no. 4451, pp. 1473 - 1475
DOI: 10.1126/science.6770464
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Articles

Science, Vol 208, Issue 4451, 1473-1475
Copyright © 1980 by American Association for the Advancement of Science

articles

Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital

JH Dees, LD Coe, Y Yasukochi, and BS Masters

The enzyme NADPH-cytochrome c (P-450) reductase was identified by indirect immunofluorescence in hepatocytes, bronchioles, and proximal tubules of liver, lung, and kidney, respectively, of rats and minipigs that had been injected with phenobarbital or saline. The distribution of this component of the cytochrome P-450-mediated microsomal system may be relevant to sites of drug toxicity and carcinogenesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Changes in Plasma Proteins in Rats Treated for Short Periods with Hepatotoxins or with Agents which Induce Cytochrome P450 Isoenzymes.
K. Makarananda, G.A. Fox, S.C. Price, and R.H. Hinton (1987)
Human and Experimental Toxicology 6, 121-126
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