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Science 27 June 1980:
Vol. 208. no. 4451, pp. 1471 - 1473
DOI: 10.1126/science.7189903
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Articles

Science, Vol 208, Issue 4451, 1471-1473
Copyright © 1980 by American Association for the Advancement of Science

articles

Niemann-Pick disease: a genetic model in Siamese cats

DA Wenger, M Sattler, T Kudoh, SP Snyder, and RS Kingston

Three Siamese cats were found to have a progressive neurological disease that became obvious when they were 4 to 5 months of age. Their brains contained an excess of GM2 and GM3 gangliosides, and their livers a nine- to tenfold excess of sphingomyelin and cholesterol. A total deficiency of lysosomal (pH 5.0) sphingomyelinase was found in the leukocytes, liver, and brain of the cats, although the activity of the microsomal (pH 7.4, magnesium-dependent) sphingomyelinase was normal in brain. These cats appear to have a genetic disease identical to Niemann-Pick disease type A.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Sphingomyelinase Deficiency (Niemann-Pick disease) in a Hereford Calf.
G. K. Saunders and D. A. Wenger (2008)
Vet. Pathol. 45, 201-202
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Science. ISSN 0036-8075 (print), 1095-9203 (online)