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Science 13 June 1980:
Vol. 208. no. 4449, pp. 1284 - 1286
DOI: 10.1126/science.7375942
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Articles

Science, Vol 208, Issue 4449, 1284-1286
Copyright © 1980 by American Association for the Advancement of Science

articles

Clinical radioimmunodetection of cancer with radioactive antibodies to human chorionic gonadotropin

DM Goldenberg, EE Kim, FH DeLand, Nagell JR van Jr, and N Javadpour

Injection of iodine-131-labeled goat immunoglobulin G antibody to human chorionic gonadotropin (hCG) into patients with hCG-secreting trophoblastic and germinal tumors permitted tumor detection and location by external gamma-ray scintigraphy. Excision of one of the metastatic tumors located by this method indicated a tumor/nontumor ration of 39.29. The method appears to offer a new clinical tool for precisely locating hCG-producing tumors in the body, even when tumor identification by other clinical methods has failed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pharmacy Considerations Related to Radiolabeled Monoclonal Antibodies.
G. H. Hinkle, R. W. Beightol, N. Gregorio, and S. R. Lefevre (1989)
Journal of Pharmacy Practice 2, 177-184
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Scintigraphy of normal mouse ovaries with monoclonal antibodies to ZP-2, the major zona pellucida protein.
I. East, A. Keenan, S. Larson, and J Dean (1984)
Science 225, 938-941
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Radioimmunodetection of Prostatic Cancer: In Vivo Use of Radioactive Antibodies Against Prostatic Acid Phosphatase for Diagnosis and Detection of Prostatic Cancer by Nuclear Imaging.
D. M. Goldenberg, F. H. DeLand, S. J. Bennett, F. J. Primus, M. O. Nelson, R. C. Flanigan, J. W. McRoberts, A. W. Bruce, and D. E. Mahan (1983)
JAMA 250, 630-635
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The Role of Radioimmunodetection in the Management of Testicular Cancer.
N. Javadpour, E. E. Kim, F. H. DeLand, J. R. Salyer, U. Shah, and D. M. Goldenberg (1981)
JAMA 246, 45-49
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Nuclear Medicine: The Internist's View.
M. L. Lecklitner and M. L. Nusynowitz (1981)
JAMA 245, 2202-2203
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