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Science 13 June 1980:
Vol. 208. no. 4449, pp. 1276 - 1278
DOI: 10.1126/science.7375938
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Articles

Science, Vol 208, Issue 4449, 1276-1278
Copyright © 1980 by American Association for the Advancement of Science

articles

Evidence for a vesicular transport mechanism in hepatocytes for biliary secretion of immunoglobulin A

RH Renston, AL Jones, WD Christiansen, GT Hradek, and BJ Underdown

Quantitative electron microscopic autoradiography and diaminobenzidine cytochemistry provide evidence for an uptake and vesicular transport mechanism for iodine-125-labeled immunoglobulin A from plasma to bile by hepatocytes in vivo. The data confirm the existence of a hepatobiliary pathway for secretion of immunoglobulin A into the intestine and are consistent with a vesicular transport mechanism for biliary proteins within liver parenchymal cells.


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