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Science 13 June 1980:
Vol. 208. no. 4449, pp. 1267 - 1269
DOI: 10.1126/science.6246584
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Articles

Science, Vol 208, Issue 4449, 1267-1269
Copyright © 1980 by American Association for the Advancement of Science

articles

Mitochondrial water in myocardial ischemia: investigation with nuclear magnetic resonance

LH Michael, P Seitz, J McMillin-Wood, D Chang, C Hazlewood, and ML Entman

Nuclear magnetic resonance studies of mitochondria isolated from ischemic hearts after coronary vessel occlusion indicated a decrease in water proton relaxation times. This change coincided with a decrease in the hydration of the samples. It is suggested that in ischemia, changes in macromolecular hydration may be one of the first mechanisms to alter function in the mitochondria, which are vital to the energy-transducing process in heart muscle.




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