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Science 13 June 1980:
Vol. 208. no. 4449, pp. 1264 - 1265
DOI: 10.1126/science.7375936
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Articles

Science, Vol 208, Issue 4449, 1264-1265
Copyright © 1980 by American Association for the Advancement of Science

articles

Kindling induces long-lasting alterations in response of hippocampal neurons to elevated potassium levels in vitro

AP Oliver, BJ Hoffer, and RJ Wyatt

The cellular basis of kindling was studied electrophysiologically with slices of guinea pig hippocampus. Normally, epileptiform activity can be induced in the slices only by combined exposure to elevated potassium levels and a chemical convulsant such as penicillin. In hippocampal slices from pentylenetetrazole-kindled animals, however, elevated potassium alone can induce seizures. These data suggest that kindling elicits long-term changes in neuronal excitability that may involve ionic mechanisms.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)