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Science 6 June 1980:
Vol. 208. no. 4448, pp. 1171 - 1173
DOI: 10.1126/science.6246583
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Articles

Science, Vol 208, Issue 4448, 1171-1173
Copyright © 1980 by American Association for the Advancement of Science

articles

Opiate receptor function may be modulated through an oxidation-reduction mechanism

G Marzullo and B Hine

Cupric ion, a thiol oxidant, caused naloxone-reversible analgesia when injected intracerebroventricularly in mice; its potency was close to that of morphine. Dithiothreitol, a thiol reductant, reversed the analgesia induced by cupric ion and antagonized analgesia induced by morphine. Oxidized dithiothreitol had no effect. These findings, together with evidence for redox modification of opiate receptor binding in vitro, suggest that a mechanism of oxidation-reduction of thiols may modulate opiate receptor function.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Insulin receptors: differences in structural organization on adipocyte and liver plasma membranes.
L Jarett, J. Schweitzer, and R. Smith (1980)
Science 210, 1127-1128
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