Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 June 1980:
Vol. 208. no. 4448, pp. 1155 - 1156
DOI: 10.1126/science.6246582
Prev | Table of Contents | Next

Articles

Science, Vol 208, Issue 4448, 1155-1156
Copyright © 1980 by American Association for the Advancement of Science

articles

Cholecystokinin receptors in the brain: characterization and distribution

A Saito, H Sankaran, ID Goldfine, and JA Williams

Specific cholecystokinin binding sites in particulate fractions of rat brain were measured with iodine 125-labeled Bolton-Hunter cholecystokinin, a cholecystokinin analog that has full biological activity. Binding was detected in brain regions known to contain immunoreactive cholecystokinin. Binding was saturable, reversible, of high affinity (dissociation constant, 1.7 x 10(-9) M), and was inhibited by cholecystokinin analogs but not by unrelated hormones.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tachykinin neurokinin 3 receptor signaling in cholecystokinin-elicited release of oxytocin and vasopressin.
G. E. Haley and F. W. Flynn (2008)
Am J Physiol Regulatory Integrative Comp Physiol 294, R1760-R1767
   Abstract »    Full Text »    PDF »
Cholecystokinin B-Type Receptors Mediate a G-Protein-Dependent Depolarizing Action of Sulphated Cholecystokinin Ocatapeptide (CCK-8s) on Rodent Neonatal Spinal Ventral Horn Neurons.
M. Oz, K.-H. Yang, T. S. Shippenberg, L. P. Renaud, and M. J. O'Donovan (2007)
J Neurophysiol 98, 1108-1114
   Abstract »    Full Text »    PDF »
Cholecystokinin and gastrin receptors..
M. Dufresne, C. Seva, and D. Fourmy (2006)
Physiol Rev 86, 805-847
   Abstract »    Full Text »    PDF »
Sulfonation and Molecular Action.
C. A. Strott (2002)
Endocr. Rev. 23, 703-732
   Abstract »    Full Text »    PDF »
CI-988 Inhibits Growth of Small Cell Lung Cancer Cells.
T. W. Moody and R. T. Jensen (2001)
J. Pharmacol. Exp. Ther. 299, 1154-1160
   Abstract »    Full Text »    PDF »
Pancreatic CCKB receptors: their potential roles in somatostatin release and delta -cell proliferation.
J. Morisset, H. Wong, J. H. Walsh, J. Laine, and J. Bourassa (2000)
Am J Physiol Gastrointest Liver Physiol 279, G148-G156
   Abstract »    Full Text »    PDF »
International Union of Pharmacology. XXI. Structure, Distribution, and Functions of Cholecystokinin Receptors.
F. Noble, S. A. Wank, J. N. Crawley, J. Bradwejn, K. B. Seroogy, M. Hamon, and B. P. Roques (1999)
Pharmacol. Rev. 51, 745-781
   Abstract »    Full Text »    PDF »
Pathways of Fos expression in locus ceruleus, dorsal vagal complex, and PVN in response to intestinal lipid.
H. Monnikes, G. Lauer, C. Bauer, J. Tebbe, T. T. Zittel, and R. Arnold (1997)
Am J Physiol Regulatory Integrative Comp Physiol 273, R2059-R2071
   Abstract »    Full Text »    PDF »
Prevention of Tolerance to the Antinociceptive Effects of Systemic Morphine by a Selective Cholecystokinin-B Receptor Antagonist in a Rat Model of Peripheral Neuropathy.
J. J. Idänpään-Heikkilä, G. Guilbaud, and V. Kayser (1997)
J. Pharmacol. Exp. Ther. 282, 1366-1372
   Abstract »    Full Text »
The cholecystokinin hypothesis of panic and anxiety disorders: a review.
J. Bradwejn, D. Koszycki, A. C. du Tertre, M. Bourin, R. Palmour, and F. Ervin (1992)
J Psychopharmacol 6, 345-351
   Abstract »    PDF »
Enhanced Sensitivity to Cholecystokinin Tetrapeptide in Panic Disorder: Clinical and Behavioral Findings.
J. Bradwejn, D. Koszycki, and C. Shriqui (1991)
Arch Gen Psychiatry 48, 603-610
   Abstract »    PDF »
Cholecystokinin Tetrapeptide Induces Panic-like Attacks in Healthy Volunteers: Preliminary Findings.
C. de Montigny (1989)
Arch Gen Psychiatry 46, 511-517
   Abstract »    PDF »
Peptide-dopamine interactions in the central nervous system: implications for neuropsychiatric disorders.
A.J. Stoessl (1989)
J Psychopharmacol 3, 99-120
   PDF »
Drug and neurotransmitter receptors in the brain.
S. Snyder (1984)
Science 224, 22-31
   Abstract »    PDF »
Proglumide: selective antagonism of excitatory effects of cholecystokinin in central nervous system.
L. Chiodo and B. Bunney (1983)
Science 219, 1449-1451
   Abstract »    PDF »
Origin of the cholecystokinin-containing fibers in the rat caudatoputamen.
D. Meyer, M. Beinfeld, W. Oertel, and M. Brownstein (1982)
Science 215, 187-188
   Abstract »    PDF »
Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat.
G. Smith, C Jerome, B. Cushin, R Eterno, and K. Simansky (1981)
Science 213, 1036-1037
   Abstract »    PDF »
Cholecystokinin antibody injected in cerebral ventricles stimulates feeding in sheep.
M. Della-Fera, C. Baile, B. Schneider, and J. Grinker (1981)
Science 212, 687-689
   Abstract »    PDF »
Brain peptides as neurotransmitters.
S. Snyder (1980)
Science 209, 976-983
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)