Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 30 May 1980:
Vol. 208. no. 4447, pp. 1044 - 1046
DOI: 10.1126/science.6246578
Prev | Table of Contents | Next

Articles

Science, Vol 208, Issue 4447, 1044-1046
Copyright © 1980 by American Association for the Advancement of Science

articles

Pro-adrenocorticotropin/endorphin-derived peptides: coordinate action on adrenal steroidogenesis

RC Pedersen, AC Brownie, and N Ling

A synthetic peptide, representing a portion of the 16K (16,000 dalton)-fragment sequence within the pro-adrenocorticotropin/endorphin precursor molecule, potentiates the steroidogenic action of the 1 to 24 portion of adrenocorticotropin [ACTH(1-24)] on the rat adrenal cortex. The peptide has 27 amino acid residues and consists of gamma-melanotropin with a carboxyl terminal extension. It affects both the inner and outer adrenocortical zones of hypophysectomized animals, as evidenced by a synergistic augmentation of corticosterone and aldosterone production, respectively. The peptide can be distinguished from adrenocorticotropin by its activation of cholesterol ester hydrolase and its failure to stimulate cholesterol side-chain cleavage.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evidence of a possible role for Lys-{gamma}3-MSH in the regulation of adipocyte function.
S. C Harmer, D. J Pepper, K. Cooke, H. P J Bennett, and A. B Bicknell (2008)
J. Endocrinol. 196, 149-158
   Abstract »    Full Text »    PDF »
Development, Maintenance, and Function of the Adrenal Gland in Early Postnatal Proopiomelanocortin-Null Mutant Mice.
J. Karpac, D. Ostwald, S. Bui, P. Hunnewell, M. Shankar, and U. Hochgeschwender (2005)
Endocrinology 146, 2555-2562
   Abstract »    Full Text »    PDF »
N-Terminal Proopiomelanocortin Acts as a Mitogen in Adrenocortical Tumor Cells and Decreases Adrenal Steroidogenesis.
M. Fassnacht, S. Hahner, I. A. Hansen, T. Kreutzberger, M. Zink, K. Adermann, F. Jakob, J. Troppmair, and B. Allolio (2003)
J. Clin. Endocrinol. Metab. 88, 2171-2179
   Abstract »    Full Text »    PDF »
Infusion of N-Proopiomelanocortin-(1-77) Increases Adrenal Weight and Messenger Ribonucleic Acid Levels of Cytochrome P450 17{alpha}-Hydroxylase in the Sheep Fetus during Late Gestation.
J. T. Ross, H. P. J. Bennett, S. James, and I. C. McMillen (2000)
Endocrinology 141, 2153-2158
   Abstract »    Full Text »    PDF »
Circadian Variation in Basal Plasma Corticosterone and Adrenocorticotropin in the Rat: Sexual Dimorphism and Changes across the Estrous Cycle.
H. C. Atkinson and B. J. Waddell (1997)
Endocrinology 138, 3842-3848
   Abstract »    Full Text »    PDF »
Immunoreactive dynorphin-(1-8) and corticotropin- releasing factor in subpopulation of hypothalamic neurons.
K. Roth, E Weber, J. Barchas, D Chang, and J. Chang (1983)
Science 219, 189-191
   Abstract »    PDF »
The carboxy terminus of the precursor to vasopressin and neurophysin: immunocytochemistry in rat brain.
S. Watson, N. Seidah, and M Chretien (1982)
Science 217, 853-855
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)