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Science 9 May 1980:
Vol. 208. no. 4444, pp. 610 - 612
DOI: 10.1126/science.6102801
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Articles

Science, Vol 208, Issue 4444, 610-612
Copyright © 1980 by American Association for the Advancement of Science

articles

Neurotransmitter receptor binding in bovine cerebral microvessels

SJ Peroutka, MA Moskowitz, JF Reinhard Jr, and SH Snyder

Purified preparations of microvessels from bovine cerebral cortex contain substantial levels of alpha-adrenergic, beta-adrenergic, and histamine 1 receptor binding sites but only negligible serotonin, muscarinic cholinergic, opiate, and benzodiazepine receptor binding. Norepinephrine and histamine may be endogenous regulators of the cerebral microcirculation at the observed receptors.


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