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Science 9 May 1980:
Vol. 208. no. 4444, pp. 605 - 607
DOI: 10.1126/science.6154316
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Articles

Science, Vol 208, Issue 4444, 605-607
Copyright © 1980 by American Association for the Advancement of Science

articles

Bladder-surface glycosaminoglycans: an efficient mechanism of environmental adaptation

CL Parsons, C Stauffer, and JD Schmidt

The transitional epithelium of the urinary bladder secretes and binds to its surface a glycosaminoglycan than inhibits the adherence of bacteria. Synthetic sulfonated glycosaminoglycans instilled intraluminally into bladders whose natural mucin layer has been removed are as effective as the natural mucin in preventing bacterial adherence. It also appears that adherence of calcium and protein is reduced in the presence of both the natural mucin layer and the synthetic sulfonated glycosaminoglycan sodium pentosanpolysulfate, suggesting that the antiadherence activity of both natural and synthetic surface glycosaminoglycans in the bladder extends to the molecular and ionic levels.


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