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Science 9 May 1980:
Vol. 208. no. 4444, pp. 601 - 603
DOI: 10.1126/science.7367883
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Articles

Science, Vol 208, Issue 4444, 601-603
Copyright © 1980 by American Association for the Advancement of Science

articles

Calcification inside artificial hearts: inhibition by warfarin-sodium

WS Pierce, JH Donachy, G Rosenberg, and RE Baier

Intracavitary calcium phosphate deposits were observed in smooth, elastomeric blood pump sacs implanted in male calves for periods of 115 to 166 days. These deposits occurred predominantly on the flexing surface of the sacs. In contrast, similar pump sacs remained generally free of mineral deposits for up to 150 days in calves treated with the anticoagulant warfarin-sodium. These results implicate a vitamin K-dependent process in calcium phosphate deposition on elastomeric sacs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Advanced Biomaterials Development from "Natural Products".
R.E. Baier (1987)
J Biomater Appl 2, 615-626
   Abstract »    PDF »
Inhibition of calcification of bioprosthetic heart valves by local controlled-release diphosphonate.
R. Levy, J Wolfrum, F. Schoen, M. Hawley, S. Lund, and R Langer (1985)
Science 228, 190-192
   Abstract »    PDF »


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