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Science 9 May 1980:
Vol. 208. no. 4444, pp. 597 - 599
DOI: 10.1126/science.7367881
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Articles

Science, Vol 208, Issue 4444, 597-599
Copyright © 1980 by American Association for the Advancement of Science

articles

Sexual characteristics of adult female mice are correlated with their blood testosterone levels during prenatal development

FS vom Saal and FH Bronson

Mice produce litters containing many pups, and the female fetuses that develop between male fetuses have significantly higher concentrations of the male sex steroid testosterone in both their blood and amniotic fluid than do females that develop between other female fetuses. These two types of females differ during later life in many sexually related characteristics. Thus, individual variation in sexual characteristics of adult female mice may be traceable to differential exposure to testosterone during prenatal development because of intrauterine proximity to male fetuses.


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