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Science 2 May 1980:
Vol. 208. no. 4443, pp. 512 - 514
DOI: 10.1126/science.6445079
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Articles

Science, Vol 208, Issue 4443, 512-514
Copyright © 1980 by American Association for the Advancement of Science

articles

Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma

CR Parker Jr, ER Simpson, DW Bilheimer, K Leveno, BR Carr, and PC MacDonald

A striking inverse correlation was found in umbilical cord plasma between the concentrations of dehydroisoandrosterone sulfate and low-density lipoprotein (LDL)-cholesterol but not high-density lipoprotein-cholesterol or very low density lipoprotein-cholesterol. Dehydroisoandrosterone sulfate is a major secretory product of the human fetal adrenal and the principal precursor of placental estrogen production. The data suggest that the concentrations for LDL-cholesterol in fetal plasma are influenced by the rate of utilization of LDL-cholesterol by the fetal adrenal for steroidogenesis and are not necessarily related to a genetic predisposition for hypercholesterolemia or other lipoprotein disorders.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effect of 12-Month Dehydroepiandrosterone Replacement Therapy on Bone, Vagina, and Endometrium in Postmenopausal Women.
F. Labrie, P. Diamond, L. Cusan, J.-L. Gomez, A. Belanger, and B. Candas (1997)
J. Clin. Endocrinol. Metab. 82, 3498-3505
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Combined Effects of Dehydroepiandrosterone and EM-800 on Bone Mass, Serum Lipids, and the Development of Dimethylbenz(A)Anthracene-Induced Mammary Carcinoma in the Rat.
S. Luo, A. Sourla, C. Labrie, A. Belanger, and F. Labrie (1997)
Endocrinology 138, 4435-4444
   Abstract »    Full Text »    PDF »
Effect of Dehydroepiandrosterone on Bone Mass, Serum Lipids, and Dimethylbenz(a)anthracene-Induced Mammary Carcinoma in the Rat.
S. Luo, C. Labrie, A. Belanger, and F. Labrie (1997)
Endocrinology 138, 3387-3394
   Abstract »    Full Text »    PDF »
X-linked ichthyosis: increased blood cholesterol sulfate and electrophoretic mobility of low-density lipoprotein.
E. Epstein Jr, R. Krauss, and C. Shackleton (1981)
Science 214, 659-660
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