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Science 2 May 1980:
Vol. 208. no. 4443, pp. 508 - 510
DOI: 10.1126/science.7367874
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Articles

Science, Vol 208, Issue 4443, 508-510
Copyright © 1980 by American Association for the Advancement of Science

articles

Phenobarbital exposure in utero: alterations in female reproductive function in rats

C Gupta, BR Sonawane, SJ Yaffe, and BH Shapiro

Phenobarbital administration to pregnant rats from day 12 to day 19 of gestation suppressed body weight gain and produced significant effects on reproductive function in their offspring. These effects included delays in the onset of puberty, disorders in the estrous cycle, and infertility. Moreover, the animals exposed to phenobarbital in utero showed altered concentrations of sex steroids, gonadotrophic hormones, and estrogen receptors. These findings suggest that phenobarbital treatment during prenatal development can produce permanent alterations in sexual maturation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antiepileptic Drugs Affect Neuronal Androgen Signaling via a Cytochrome P450-Dependent Pathway.
M. Gehlhaus, N. Schmitt, B. Volk, and R. P. Meyer (2007)
J. Pharmacol. Exp. Ther. 322, 550-559
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Latent Overexpression of Hepatic CYP2C7 in Adult Male and Female Rats Neonatally Exposed to Phenobarbital: A Developmental Profile of Gender-Dependent P450s.
A. K. Agrawal and B. H. Shapiro (2000)
J. Pharmacol. Exp. Ther. 293, 1027-1033
   Abstract »    Full Text »
Pregnancy increases reactivity of mice to phenobarbital.
L. Middaugh, J. Zemp, and W. Boggan (1983)
Science 220, 534-536
   Abstract »    PDF »
Prenatal exposure to phenobarbital permanently decreases testosterone and causes reproductive dysfunction.
C Gupta, S. Yaffe, and B. Shapiro (1982)
Science 216, 640-642
   Abstract »    PDF »


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