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Science 2 May 1980:
Vol. 208. no. 4443, pp. 505 - 508
DOI: 10.1126/science.6768132
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Articles

Science, Vol 208, Issue 4443, 505-508
Copyright © 1980 by American Association for the Advancement of Science

articles

L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis

Fozard JR, ML Part, NJ Prakash, J Grove, PJ Schechter, A Sjoerdsma, and J Koch-Weser

The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and arrests embryonic development at that stage. Contragestational effects were confirmed in the rat and rabbit. An increase in L-ornithine decarboxylase activity that leads to a rapid increase in putrescine concentration appears to be essential during a critical period after implantation for continued mammalian embryonal growth.


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