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Science 25 April 1980:
Vol. 208. no. 4442, pp. 415 - 416
DOI: 10.1126/science.7189295
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Articles

Science, Vol 208, Issue 4442, 415-416
Copyright © 1980 by American Association for the Advancement of Science

articles

Regression of tumors in guinea pigs after treatment with synthetic muramyl dipeptides and trehalose dimycolate

CA McLaughlin, SM Schwartzman, BL Horner, GH Jones, JG Moffatt, JJ Nestor Jr, and D Tegg

A high incidence of tumor regression was observed in guinea pigs bearing transplantable, line-10 hepatocellular carcinomas when synthetic muramyl dipeptides combined with trehalose dimycolate in oil-in-water emulsions were injected directly into the tumors. These compounds are promising candidates to replace viable bacillus Calmette-Guerin in cancer immunotherapy in humans and animals.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)