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Science 25 April 1980:
Vol. 208. no. 4442, pp. 410 - 412
DOI: 10.1126/science.7189293
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Articles

Science, Vol 208, Issue 4442, 410-412
Copyright © 1980 by American Association for the Advancement of Science

articles

Somatomedin C: restoration in vivo of cycle traverse in G0/G1 blocked cells of hypophysectomized animals

H Rothstein, JJ Van Wyk, JH Hayden, Gordon SR, and A Weinsieder

DNA synthesis and mitosis in frog lens epithelium are abolished by hypophysectomy and restored by somatomedin C. Both growth hormone and triiodothyronine also restore lens cell proliferation in vivo but not in vitro. Somatomedin-like activity in frog serum is diminished by hypophysectomy and is restored by growth hormone and triiodothyronine.


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Arch. Dis. Child. 76, 304-309
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Regulation of lens cell growth and polarity by an embryo-specific growth factor and by inhibitors of lens cell proliferation and differentiation.
G. Hyatt and D. Beebe (1993)
Development 117, 701-709
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Science. ISSN 0036-8075 (print), 1095-9203 (online)