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Science 25 April 1980:
Vol. 208. no. 4442, pp. 404 - 406
DOI: 10.1126/science.7367866
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Articles

Science, Vol 208, Issue 4442, 404-406
Copyright © 1980 by American Association for the Advancement of Science

articles

Hydralazine-pyrimidine interactions may explain hydralazine-induced lupus erythematosus

LM Dubroff and RJ Reid Jr

Hydralazine, the prototypic drug that induces systemic lupus erythematosus, reacts with thymidine and deoxycytidine. Analysis of a reaction mixture of therapeutic concentrations of hydralazine with labeled thymidine reveals at least four labeled products. At higher concentrations, hydralazine reacts with labeled deoxycytidine to form at least three labeled products. Formation of these products is markedly enhanced by exposure to ultraviolet light. The reaction of hydralazine with thymidine and deoxycytidine may be in part responsible for initiating drug-induced systemic lupus erythematosus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Minoxidil-Induced Systemic Lupus Erythematosus.
A. R. Tunkel, M. Shuman, M. Popkin, R. Seth, and B. Hoffman (1987)
Arch Intern Med 147, 599-600
   Abstract »    PDF »
Genotoxicity of the antihypertensive drugs hydralazine and dihydralazine.
G. Williams, G Mazue, C. McQueen, and T Shimada (1980)
Science 210, 329-330
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)