Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 25 April 1980:
Vol. 208. no. 4442, pp. 402 - 404
DOI: 10.1126/science.6245446
Prev | Table of Contents | Next

Articles

Science, Vol 208, Issue 4442, 402-404
Copyright © 1980 by American Association for the Advancement of Science

articles

Tumor-promoting phorbol esters stimulate hematopoietic colony formation in vitro

RK Stuart and JA Hamilton

Tumor-promoting phorbol esters stimulated mouse bone marrow cells to form myeloid colonies in agar cultures without added colony-stimulating factors. The colony-stimulating ability of various phorbol esters correlated well with their ability to promote skin tumors in vivo. These results suggest that phorbol esters mimic the action of specific colony-stimulating factors that regulate growth.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phorbol Ester Enhancement of IL-3-Dependent Proliferation of Primitive Hematopoietic Progenitors of Mice in Culture.
M. Musashi, K. Sakurada, K.-I. Kawamura, H. Iwasaki, Y. Tsuda, M. Kobayashi, M. Sasaki, K. Kato, E. Tanaka, T. Sudo, et al. (1997)
J. Pharmacol. Exp. Ther. 280, 225-231
   Abstract »    Full Text »
Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans.
Y Tabuse, K Nishiwaki, and J Miwa (1989)
Science 243, 1713-1716
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)