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Science 18 April 1980:
Vol. 208. no. 4441, pp. 299 - 300
DOI: 10.1126/science.7367859
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Articles

Science, Vol 208, Issue 4441, 299-300
Copyright © 1980 by American Association for the Advancement of Science

articles

Genetic expression of Wilson's disease in cell culture: a diagnostic marker

WY Chan, W Cushing, MA Coffman, and OM Rennert

Wilson's disease fibroblasts have an elevated intracellular copper concentration as compared to cultured control cells. A decreased ratio of copper to protein was observed in cytoplasmic protein (or proteins) having a molecular weight greater than or equal to 30,000 in Wilson's disease cells. The results of this culture study indicate its potential importance in the early unequivocal diagnosis of this disorder.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Treatment of Wilson's Disease.
A. DEISS (1983)
Ann Intern Med 99, 398-400
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