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ArticlesCopyright © 1980 by American Association for the Advancement of Science
Genetic expression of Wilson's disease in cell culture: a diagnostic marker
Wilson's disease fibroblasts have an elevated intracellular copper concentration as compared to cultured control cells. A decreased ratio of copper to protein was observed in cytoplasmic protein (or proteins) having a molecular weight greater than or equal to 30,000 in Wilson's disease cells. The results of this culture study indicate its potential importance in the early unequivocal diagnosis of this disorder.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)